LGALS9 and neoplasm: Since derived from normal cells, tumor cells can develop several survival features to get immune tolerance, including reduced tumor antigens (CA15-3, CEA, PCNA, etc.), increased resistance or survival (STAT-3 or anti-apoptotic molecule Bcl2), or development of an immunosuppressive TME (releasing cytokines such as VEGF, TGF-β, or expressing immunoregulatory molecules such as IDO, PD-L1, Tim-3/galectin-9, and CTLA-4/CD80) (57).