TREM2 and amyotrophic lateral sclerosis: There seems to be a Trem2-dependency from the second step onward together with the upregulation of genes involved in lipid metabolism and phagocytic activity, such as Lpl, Cst7, Axl, and Clec7a. DAMs have also been identified in postmortem human AD tissue and in a mouse model for ALS (mSOD1 mice).