TYROBP and Alzheimer disease: Plaque-associated microglia in the 5XFAD AD-mouse model (co-expresses five mutations associated with familial AD) contain upregulated sets of genes that overlap with the primed microglia transcriptional profile (95), that is characterized by enrichment of genes involved in among others immune and phagocytic processes, like Apoe, Axl, and Clec7a. Key protein regulators of those upregulated genes are Tyrobp (Dap12) and CD11c (Itgax).