In this study, although the mRNA levels of Th1-associated cytokines (IFNγ and IL-1β) and Th2-associated cytokines (IL-4 and IL-10) were increased in the brain tissues of both C57BL/6 and BALB/c mice infected with T. gondii Pru strain, susceptible C57BL/6 mice presented a dominant Th1 response characterized by high expression of IFNγ at all the times after infection, accompanied by stronger neuroinflammatory outcomes. This evidence concerns the gene IFNG and infection.