Herein we have demonstrated that overexpression of p53, accompanied with gain-and-loss of expression of downstream transcription factors such as E-Cadherin, CALD1, SNAI-1 and SLUG, following the exposure of CRC cells to cisatracurium results in the suppression of CRC cells/tumor growth as well as significant regression of migration and invasion. The gene discussed is TP53; the disease is colorectal carcinoma.