Alternatively, Caspase-2 is activated through p53- induced protein with a death domain (PIDD), culminating into the discharge of Cytochrome C. The induction of apoptosis is critical as it delays cancer proliferation, thereby retarding the progression of onco-genes conversion and generally restricting tumorigenesis (Yin et al., 1997; Lowe et al., 2004). The gene discussed is TP53; the disease is cancer.