The findings of this work suggest that elevation of p53, p21, E-Cadherin, CALD1 with downregulation of CD1, SNAI-1 and SLUG upon DNA damage, following cisatracurium exposure represent the potential mechanism by which cisatracurium causes the inhibition of CRC cells/tumor growth, and regression of migration and invasion. The gene discussed is TP53; the disease is neoplasm.