mGlu5 receptors are also present in parvalbumin-positive interneurons and parvalbumin-cell ablation of either NMDA or mGlu5 receptors alters the development and function of these neurons inducing core features of schizophrenia and other neurodevelopmental disorders (Belforte et al., 2010; Billingslea et al., 2014; Barnes et al., 2015). This evidence concerns the gene PVALB and schizophrenia.