Nowadays, breast cancer is no longer considered as a single disease but a systemic diseases, and the complete diagnosis dependent on the histopathology report of the tumor which assess the presence or absence of the hormone receptors for estrogen (ER), progesterone (PR), and the human epidermal growth factor receptor-2 (HER-2) (Shaikh et al., 2016). The gene discussed is ERBB2; the disease is neoplasm.