CDH1 and neoplasm: During the EMT process of tumor metastasis, the cancer cells complete the shift from the adhesive, non-mobile, oval epithelial phenotype to the mobile, invasive long spindle mesenchymal phenotype, meanwhile, the epithelial cell markers like E-cadherin and Claudin were down-regulated but the mesenchymal cell markers such as N-cadherin and Vimentin were up-regulated (Banyard and Bielenberg, 2015).