APP and Alzheimer disease: Eisele et al. (2010) further showed that intraperitoneally applied Aβ-containing inoculates induced cerebral β-amyloidosis in Amyloid precursor protein carrying the Swedish mutation (APP23) transgenic mice, whereas 500 μL of AD brain extract (10% wt/vol in Phosphate buffer saline, PBS) administered orally daily for 5 days failed to induce cerebral β-amyloidosis in APP23 transgenic hosts (Eisele et al., 2009), which came into conflict.