Netrin binding to the receptor deleted in colorectal cancer (DCC) results in attractive responses, via homodimerization of DCC (covered in detail in later sections) (Chan et al., 1996; Keino-Masu et al., 1996; Kolodziej et al., 1996; Fazeli et al., 1997), whereas heterodimerization between DCC and receptor uncoordinated locomotion 5 (UNC5) converts this attractive response into repulsion (Hamelin et al., 1993; Colavita and Culotti, 1998; Finci et al., 2014). The gene discussed is DCC; the disease is colorectal cancer.