DAGLA and Anxiety: That acute pharmacological DAGL inhibition is associated with impaired extinction of conditioned fear is also globally consistent with the increased unconditioned anxiety and increased stress-susceptibility observed after DAGL inhibition and in DAGLα−/− mice (Shonesy et al., 2014; Jenniches et al., 2016; Bedse et al., 2017; Bluett et al., 2017).