Our previous study showed that the anti-neuroinflammatory effects of melatonin inhibited the activation of NF-κB and decreased TNF-α mRNA levels in methamphetamine-induced pro-inflammatory mediators (Permpoonputtana and Govitrapong, 2013[35]; Wongprayoon and Govitrapong, 2015[50]) and in the H2O2-induced senescence state (Nopparat et al., 2017[30]) of human neuroblastoma dopamine SH-SY5Y cell lines. The gene discussed is TNF; the disease is neuroblastoma.