NFKB1 and neurodegenerative disease: The elevation of NFĸB has been reported in old age (Calabrese et al., 2011[9]) and activation of NFκB, stimulation of other inflammatory mediators, and glial activation lead to progression of age-related diseases and other neurodegenerative diseases (Bierhaus et al., 2005[6]; Srikanth et al., 2011[45]).