NFKB1 and Alzheimer disease: The elevation of pNFĸB has been represented in a senescence model (Calabrese et al., 2011[9]; Nopparat et al., 2017[30]), and NFκB signaling has been shown to induce the production of pro-inflammatory cytokines leading to increasing age-related diseases such as memory impairment and AD (Ali et al., 2015[2]; Srikanth et al., 2011[45]).