In regard to the ability of NGR to recognize the tumor specific isoform of CD13 and also αѴβ3, many studies have used NGR for carrying cytotoxic drugs such as DOX, anti-angiogenic drugs ((KLAKLAK)2 and endostatin), cytokines (INF-γ,TNF-α) and probe to tumor tissues (Bouchet et al., 2016[3]; Corti, 2004[4]; Curnis et al., 2005[8], 2000[9]; Ellerby et al., 1999[11]; Garde et al., 2007[13]; Meng et al., 2007[20]; Sacchi et al., 2006[23]). Here, TNF is linked to neoplasm.