Three novel genes (CACNB3, HHIP-AS1, and RP11-68L1.1) were exome-wide statistically significant in the CH group in analyses restricted to variants with CADD scores ≥ 20 (Supplementary Table S5), however these are likely false positives because in each instance the result is accounted for by a single variant that was observed in one person only. Here, CACNB3 is linked to cyclic hematopoiesis.