Our WES study, the largest for AD conducted to date, identified novel associations with variants in three genes not previously implicated in AD including one common nearly exome-wide significant variant each in IGHG3 (p = 9.8 × 10−7) and STAG3 (p = 8.8 × 10−7), and one rare exome-wide significant variant in AC099552.4 (p = 1.2 × 10−7). Here, STAG3 is linked to Alzheimer disease.