In addition, stimulation of Q7 cells, a striatal cell line obtained from wild-type mice, showed an outwardly rectifying I/V shape for TRPC1/5, whereas in Q111 cells, a Huntington’s disease cell line obtained from mutant HTT knock-in mice, a doubly rectifying I/V shape was observed for TRPC5 because the expression of TRPC1 was suppressed44. Here, TRPC5 is linked to juvenile Huntington disease.