Furthermore, mutations in genes associated with the Wnt-β catenin pathway, which is commonly affected in CRC, were also observed in this patient, including loss of function mutations in the APC and AXIN2 genes, the protein products of which normally work in concert to stabilize the β-catenin protein and to prevent it from translocating into the nucleus to activate aberrant cell proliferation and cell survival programs29. Here, AXIN2 is linked to colorectal carcinoma.