CD8A and neoplasm: Based on our observations, we propose two mechanisms that could explain T cell suppression in the LS patient (II.2) tumour: a) the finding of two truncating mutations in the HLA-A*02 allele which may have rendered the tumour partially invisible to the infiltrating CD8+ T cells, given that a significant proportion of the predicted immunogenic peptides in this tumour were restricted to HLA-A*02 and b) the high infiltration of Treg and MDSC cells in the tumour microenvironment.