MUC5AC and colon adenocarcinoma: While one of the three individuals carrying the mutation was unaffected (V.2, aged 51, no progression to CRC), the other two individuals (IV.1 aged 46 and V.1 aged 57) were diagnosed with adenocarcinoma of the colon (mucinous, with extracellular mucin >50%) and were operated to remove the tumour.