FBL and systemic sclerosis: Shp2 Fib KO mice were protected from experimental fibrosis induced by overexpression of a constitutively active TGFβ receptor type I. Moreover, fibroblast-specific inactivation of Shp2 also protected from bleomycin-induced skin fibrosis and ameliorated fibrosis in TSK1 mice, thereby confirming the central regulatory function of Shp2 on TGFβ signaling and fibroblast activation in multiple complementary models of SSc.