To demonstrate the role of SOX2 in nasopharyngeal carcinoma tumorigenesis, we first compared the expression of SOX2 in C666-1, SUNE-1, HNE-1, CNE1, and CNE2 nasopharyngeal carcinoma cell lines and NP69 normal nasopharyngeal cell line. The gene discussed is SOX2; the disease is nasopharyngeal carcinoma.