PIK3CA and colorectal carcinoma: Among the top ten genes, three well‐established MSI CRC driver genes (BRAF, CTNNB1, and PIK3CA) were found (Dataset EV2) (Shitoh et al, 2001; Davies et al, 2002; Fearon, 2011), providing confidence in the MutSigCV approach to identify MSI CRC driver genes.