These include heparin-binding EGF-like growth factor (HB-EGF), involved in vascular remodeling; the chemokine (C-X-C motif) ligand 1 (CXCL1), involved in angiogenesis, arteriogenesis, inflammation, and wound healing; pentraxin-3 (PTX3), an acute-phase-response protein that regulates angiogenesis after ischemia; and proliferin, a prolactin/growth hormone-like peptide with angiogenic properties. The gene discussed is XCL1; the disease is ischemia.