Endoglin and ALK1 play a key role in angiogenesis (López-Novoa and Bernabeu, 2010; Núñez-Gómez et al., 2017; Mahmoud et al., 2011; Roman and Hinck, 2017), and targeting these proteins has been used as a therapeutic approach to treat tumor angiogenesis. Here, ACVRL1 is linked to neoplasm.