AKT1 and ovarian neoplasm: Another study showed only 36% SGK3 activation was detected in a panel of ovarian tumor samples presenting with low levels of phosphorylated AKT but with high levels of PIK3CA, an encoding gene of P110 alpha subunit in class I PI3-K, and no correlation was found between SGK3 phosphorylation and phosphorylated PIK3CA overexpression or AKT activation.34