cDC1 have the unique ability of cross presentation of (tumour) antigen epitopes embedded in class I major histocompatibility complex molecules [HLA I (mice) and MHC I (human)], which is a prerequisite for the recognition of these (tumour) antigens by CD8+ T-cells and their subsequent priming, maturation, activation and proliferation. The gene discussed is MPPE1; the disease is neoplasm.