In the study of the correlation between Beclin-1 expression and liver cirrhosis, Beclin-1 expression was lower in patients with cirrhosis than in those without cirrhosis (OR = 1.95, 95% CI = 1.04–3.66, P = 0.04) after removing Lee et al.’s study [22], and heterogeneity was still obvious (P = 0.06, I2 = 50%). Here, BECN1 is linked to Cirrhosis.