Given the previous reports showing that Cur decreased AD-like pathology in APP/PS1 mice (Huang et al., 2012; Feng et al., 2016), we aimed to investigate whether PLGA-PEG-B6/Cur nanoparticles could further attenuate AD-related Aβ plaques formation in AD model mice. The gene discussed is PSEN1; the disease is Alzheimer disease.