In our study, we would investigate the drug loading capacity, drug release kinetics, blood compatibility, cell viability, and cellular uptake of PLGA-PEG-B6/Cur in vitro and administrated it into APP/PS1 transgenic mice to evaluate its effect on cognitive impairment, Aβ, and tau pathologies by conducting Morris water maze, Bielschowsky silver staining, immunostaining, and western blotting. Here, PSEN1 is linked to Cognitive impairment.