Activation of AMPK using metformin or AICAR markedly inhibited the invasion of UOK262 cells, a cell line derived from a patient with recurrent hereditary leiomyomatosis and renal cell cancer kidney cancer, by modulating HIF‐1α, which raises the potential for targeted therapeutic approaches for the treatment of renal kidney cancer‐associated kidney cancer (Tong et al., 2011). This evidence concerns the gene HIF1A and hereditary leiomyomatosis and renal cell cancer.