Finally, although our study demonstrated a role for UBXN2A in negative regulation of mot‐2 via the CHIP E3 ubiquitin ligase, it is possible that the UBXN2A/CHIP complex may also negatively regulate other oncoproteins or their tumorigenic pathways activated in both primary and metastatic tumors. Here, UBXN2A is linked to metastatic neoplasm.