Mot‐2, also called mitochondrial heat‐shock protein 70, heat‐shock protein A9 (HSPA9), or glucose‐regulated protein 75 (GRP75), is a member of the HSP70 chaperone family and has been shown to hold specific tumorigenic roles in different tumors, including CRC (Ando et al., 2013; Black and Rezvani, 2016; Cui et al., 2017; Dundas et al., 2005; Jin et al., 2016; Lu et al., 2011a; Starenki et al., 2015). Here, HSPA9 is linked to colorectal carcinoma.