CHIP, as part of the HSP70 complex, performs different functions in various human cancers, including a tumor suppressor function in colorectal, breast, prostate, and gastric cancers (Blessing et al., 2014; Luo et al., 2010; Sarkar et al., 2014; Tsuchiya et al., 2014; Wang et al., 2013, 2014b; Xu et al., 2011). This evidence concerns the gene STUB1 and cancer.