While UBXN2A overexpression decreases mot‐2 protein levels through the ubiquitin–proteasome pathway, mot‐2 can be upregulated transcriptionally in response to genotoxic stress in colon cancer cells (Grimmig et al., 2017; Swindell et al., 2007) induced by 5‐FU treatment. Here, UBXN2A is linked to malignant colon neoplasm.