https://www.ncbi.nlm.nih.gov/pubmed/?term=Fadlelmola%20FM%5BAuthor%5D&cauthor=true&cauthor_uid=18179710Fadlelmola et al. [29] investigated HL-derived cell lines and ALCL cell lines, and identified disease-associated gene copy number gains and losses, and confirmed the amplification of all three isoforms of the trypsin gene (PRSS1/PRSS2/PRSS3). This evidence concerns the gene PRSS2 and anaplastic large cell lymphoma.