Overall, a steady increase in ALT/AST activity and hydroxyproline levels accompanied the progression of liver fibrosis, with the highest levels evident in patients with fibrotic stage S4, as expected (Figure 1A, P < 0.05 for ALT and AST; Figure 1B, P < 0.001 for hydroxyproline vs the S0 group). The gene discussed is GPT; the disease is Hepatic fibrosis.