Previous studies reported that SMAD proteins can bind to BRD4 in response to TGF‐β stimulation.14 BRD4 is a global regulator of enhancer−mediated profibrogenic gene expression in HSCs.15 There is evidence from various cancer cell types that BRD4 can interact with the C‐MYC promoter and directly regulate its transcriptional expression.16, 17, 18 Furthermore, recent studies by one research group into the role of BRD4 in bladder cancer reported that BRD4 positively regulates enhancer of zeste homologue 2 (EZH2) transcription through the upregulation of the C‐MYC promoter.19, 20. The gene discussed is BRD4; the disease is urinary bladder cancer.