After injecting CRH into bilateral medial amygdaloidal nucleus, rats exhibited anxiety‐like behaviors that were reversed by CRH receptor 1 (CRHR1) antagonist antalarmin, indicating that CRH is directly involved in the formation of negative emotions via CRHR1 (Phelps & LeDoux, 2005; Vicentini, Cespedes, Nascimento, Bittencourt, & Viana, 2014). This evidence concerns the gene CRH and Anxiety.