Subsequent studies showed that HOXB13‐AS1 was highly expressed in human prostate, uterus, distal colon, and stomach tissues.30, 31 Moreover, another study also reported that HOXB13‐AS1 promoted breast cancer initiation and progression by activating PI3K‐AKT‐mTOR pathway.32 However, the expression and biological roles of HOXB13‐AS1 in glioma have not been fully characterized. This evidence concerns the gene HOXB13 and central nervous system cancer.