2005; Szerafin et al. 2006; Bagi 2009; Salvemini et al. 2013). We assessed responses to ACh in arteries from WT and cav‐1 KO mice on the different fatty acid diets following inhibition of Cox with indomethacin (10 μmol/L). Indomethacin had no effect on dilation to ACh in gracilis arteries from WT or cav‐1 KO mice on either LF or HF diets (Fig. 8). In contrast, indomethacin significantly reduced dilation to ACh in arteries from both WT and cav‐1 KO mice on MO (Fig. 8). This evidence concerns the gene CAV1 and hydrops fetalis.