For example, within our clinical setting, NSCLC samples now require a plethora of testing across multiple modalities: ALK IHC, ALK FISH, ROS1 IHC, ROS1 FISH, PDL1 IHC and PCR for EGFR and KRAS from normally small biopsies with limited material available. Here, ROS1 is linked to non-small cell lung carcinoma.