CXCR4 and non-Hodgkin lymphoma: As a likely consequence of its high physiological expression on normal hematopoietic cells, CXCR4 surface levels are also particularly high in several hematologic malignancies, including non-Hodgkin lymphoma (NHL), multiple myeloma (MM), chronic lymphocytic leukemia (CLL) and acute myeloid leukemia (AML), with substantial heterogeneity between diseases and within single entities.