Decreased levels/activity of thrombopoietin (TPO), use of chemotherapy for hepatic cancers, bone marrow inhibition by excessive alcohol ingestion, hypersplenism, antiplatelet antibodies, and antiviral treatment-induced myelosuppression may all contribute to the development of thrombocytopenia in CLD [2]. The gene discussed is TPO; the disease is congenital secretory chloride diarrhea 1.