In a similar experimental system, the use of 5-FU, DNA, and RNA synthesis inhibitor in combination with RPL3 overexpression considerably enhances sensitivity of 5-FU-resistant lung and colon cancer cells to this drug, and thereby, it strongly increases cytotoxic effect by means of the mitochondrial apoptotic cell response which prevents cell migration and invasion. The gene discussed is RPL3; the disease is malignant colon neoplasm.