PODXL and oral cavity squamous cell carcinoma: [21]. To investigate the function of PODXL in the growth of oral cancer cells, we previously generated PODXL-knock out (PODXL-KO) cell lines using SAS OSCC cell lines. The growth of SAS/PODXL-KO cell lines (BINDS-01) was observed to be lower than that of parental SAS cells. In this study, we further established PODXL-KO OSCC cell lines using HSC-2 (oral squamous cell carcinoma from oral cavity) cells and investigated the role of PODXL in the growth of OSCC cell lines both in vitro and in vivo.