Furthermore, we previously demonstrated that caspase-10 positively correlates with pIRF7, and caspase-9 and caspase-10 both positively correlate with each other, pIRF7, and MAVS 70 kD [30], indicating that interferons are links to cellular apoptosis and anti-virus immunity in SLE [16, 40–42]. Here, CASP10 is linked to systemic lupus erythematosus.