Mice devoid of any CatSper α subunits or the CatSper δ do not display the ICatSper and, as previously mentioned, are all infertile (Carlson et al., 2003, 2005; Kirichok et al., 2006; Liu et al., 2007; Qi et al., 2007; Wang et al., 2009; Chung et al., 2011). This evidence concerns the gene CATSPER1 and Infertility.