FGF2 and diabetes mellitus: Recently, management of chronic ulcer mainly includes debridement (mupirocin ointment, nitrofurazone solution, and rb-bFGF spray), physiotherapy (He-Ne lasers, infrared ray, and ultrashort wave), surgery, symptomatic treatment (anti-infection, anti-inflammation, pain easing, etc.), managing multifactorial diseases (diabetes, varicosity, hypertensive disease, etc.), and TCM therapy [24, 27, 28].