7.5-month-old male senescence-accelerated mouse prone 8 (SAMP8) mice were used as an AD animal model, and immunohistochemistry and Western blot were used to examine the expression of IL-1β, NLRP3, ASC, and Caspase-1 proteins in hippocampus of the brain. This evidence concerns the gene NLRP3 and Alzheimer disease.