In this study, we established COPD and COPD with cold-dryness syndrome model rats and proved that Chinese medicine formula MZP is effective in elevating lung functions in rats of COPD with cold-dryness syndrome, possibly through eliminating lung inflammatory responses and preventing the loss of AQP4/5 and the hyperproduction of Muc5AC in lung. This evidence concerns the gene MUC5AC and chronic obstructive pulmonary disease.