CXCL8 and skin basal cell carcinoma: Up-regulation of IL-8 in the presence of BAd increased the dissemination capacity of BCC by several different mechanisms: (1) by increasing angiogenesis at the primary tumor site, (2) by increasing other cytokines, which in turn enhanced BCC dissemination, (3) by inducing a pro-tumorigenic phenotype of neutrophils, and (4) by modifying the expression of cell-adhesion molecules in BCC and neutrophils.