Intriguingly, MYPT1 is also a targeting subunit of OGT in neuroblastoma cells (73), raising the tantalizing possibilty that MYPT1 targets both PP1β and OGT to the same substrate, so that the substrate protein could be dephosphorylated and O-GlcNAcylated simultaneously. The gene discussed is PPP1R12A; the disease is neuroblastoma.