ER stress sensors activate downstream factors, including C/EBP homologous protein (CHOP), c-Jun N-terminal kinase (JNK), and caspase12, and finally contribute to the generation of unhealthy myocytes, followed by a cardiac failure (Ron and Walter, 2007; Minamino and Kitakaze, 2010; Cominacini et al., 2015; Wang et al., 2017). Here, DDIT3 is linked to heart failure.