Treatment of FMR1 knockout mice, an animal model of FXS, with the selective BK channel opener BMS-204352 reversed the abnormal dendritic spine phenotype in vitro. Additionally, direct injection of the activator restored hippocampal glutamate homeostasis and corrected disturbances in social recognition and interaction, non-social anxiety and spatial memory (Hebert et al., 2014). This evidence concerns the gene KCNMA1 and fragile X syndrome.