TMEM59 and central nervous system cancer: Dendritic cell-derived factor 1 (Dcf1) is a membrane protein that plays an important role in neural stem cell differentiation, glioma apoptosis, dendritic spine formation, and social interaction, as well as amyloid precursor protein metabolism (Wen et al., 2002; Wang et al., 2008; Ullrich et al., 2010; Xie et al., 2014; Liu et al., 2017a,b).