In the BPH group average serum AMACR, urine AMACR, serum Netrin 1 and urine Netrin 1 levels were 13.4 ±16.9 ng/mL (2.8-92.4 ng/mL); 7.1 ±3.4 ng/mL (1.5-36 ng/mL); 164.1 ±46.0 pg/mL (29.6-281.7 pg/mL) and 19.5 ±5.3 pg/mL (11.8-37.0 pg/mL) respectively. This evidence concerns the gene NTN1 and benign prostatic hyperplasia.