Of the cell lines tested, we identified three clones (henceforth referred to as HIF2A-mCherry-single-cell-clone 1–3 or H2AmC1–3), all derived from UOK101 cells, a ccRCC-derived VHL-mutant cell line that transcriptionally resembles ccRCCs with poor prognosis18,19, with the correct integration pattern both at the genomic and cDNA level (Fig. 1c,d). Here, EPAS1 is linked to nonpapillary renal cell carcinoma.