Of the cell lines tested, we identified three clones (henceforth referred to as HIF2A-mCherry-single-cell-clone 1–3 or H2AmC1–3), all derived from UOK101 cells, a ccRCC-derived VHL-mutant cell line that transcriptionally resembles ccRCCs with poor prognosis18,19, with the correct integration pattern both at the genomic and cDNA level (Fig. 1c,d). This evidence concerns the gene VHL and nonpapillary renal cell carcinoma.