Four miRNAs, including miR-365, miR-125a-3p, miR-574-5p, and miR-1246, were significantly downregulated in sporadic parathyroid tumors, whereas miR-142-3p, let-7i, miR-125a-5p, miR-199b-5p, and miR-1274b_v16.0 were significantly upregulated; miR-193b was downregulated in MEN1 parathyroid tumors. The gene discussed is MEN1; the disease is tumor of parathyroid gland.