To identify molecular dependencies and potential therapeutic targets in BL, we measured the effect of 32 drugs in 10 concentrations on the viability of 42 blood cancer cell lines, including 17 BL cell lines, and 6 isogenic BL lines with targeted deletion of p53, SYK, BTK, BLK or CD20 (Fig. 1A). This evidence concerns the gene SYK and hematopoietic and lymphoid system neoplasm.