The enrichment of EGFR and MYC amplification, together with PTEN deletion in cold tumours pan-cancer was striking given the co-expression module linked to increased tumour cell glycolysis and immune evasion in HNSCC, which includes EGFR and in which pathway analysis also predicts increased c-MYC and mTORC1 activity17. This evidence concerns the gene PTEN and head and neck squamous cell carcinoma.