Multivariate analysis including variables that had prognostic significance in univariate analysis (Supplementary Table S1) in the 176 MDS patients showed that a high global aberrant AS score was an independent unfavorable prognostic factor for both OS and TTLC irrespective of age, revised international prognostic scoring system (IPSS-R) risk, and mutations in SRSF2, ZRSR2, ASXL1, TP53, and EZH2 (Table 3). The gene discussed is EZH2; the disease is myelodysplastic syndrome.